1997/09 – 2001/06，北京大学，生命科学学院，环境生物与生态，学士

2001/09 – 2006/06，北京大学，生命科学学院，神经生物学，博士  

脑衰老与神经退行性疾病的发生发展机制；

新型质谱技术研发及其在神经科学中的应用；

感知觉的中枢神经环路和调控机制；

离子通道调控机制。  

2006/10 - 2011/10， National Institutes of Health ， Postdoc

2011/10 – 2013/03， National Institutes of Health ， Research Fellow

2013/03 – 至今，中国科学技术大学，生命科学与医学部，教授

2019/11-至今，合肥综合性国家科学中心人工智能研究院，副院长

2020/01-至今，中国科学技术大学生命科学学院，副院长  

国家杰出青年科学基金、科技部 “中青年科技创新领军人才”、“万人计划”科技创新领军人才、中科院优秀导师、中国科学技术大学杰出研究校长奖、唐立新优秀学者奖 

1.  国家自然科学基金重大研究计划重点支持项目， 91849206 ，脑衰老及退行性病变的多尺度全脑胆固醇图谱研究， 2019/01-2022/12  ，  主持

2.  中国科学院战略性先导科技专项（ B 类） “ 衰老的生物学基础和干预策略 ” ，  XDB39000000 ，衰老研究的新技术与新方法， 2020/01-2024/12  ，  主持

3.  科技部十三五国家重点研发计划干细胞及转化研究专项，神经系统多能干细胞谱系分化与命运决定机制研究， 2020YFA0112200 ， 2020/09-2025/08  ，  参与  

1.	Weiwei Guo#, Sijia Fan#, Dan Xiao, Chen He, Mengyuan Guan & Wei Xiong*. A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions. Molecular Psychiatry, https://doi.org/10.1038/s41380-022-01782-6 (2022)
2.	Guichang Zou#, Jing Xia#, Heyi Luo, Dan Xiao, Jin Jin, Chenjian Miao, Xin Zuo, Qianqian Gao, Zhi Zhang, Tian Xue, Yezi You, Ye Zhang, Li Zhang & Wei Xiong*. Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism, 4:1138–1149 (2022)
3.	Weiwei Guo#, Sijia Fan#, Dan Xiao, Hui Dong, Guangwei Xu, Zhikun Wan, Yuqian Ma, Zhen Wang, Tian Xue, Yifeng Zhou, Yulong Li, Wei Xiong*. A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications, 12, 6403, https://doi.org/10.1038/s41467-021-26723-9 (2021)
4.	Hongying Zhu#, Qianqian Li#, Tiepeng Liao#, Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang*, Wei Xiong*. Metabolomic profiling of single enlarged lysosomes. Nature Methods, 18(7):788-798 (2021).
5.	Yujun Guo#, Guichang Zou#, Keke Qi, Jin Jin, Lei Yao, Yang Pan, Wei Xiong*. Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice. Molecular Brain, 14(1): 41 doi: 10.1186/s13041-021-00758-x. (2021)
6.	Jin Ye#, Guichang Zou#, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li*, Wei Xiong*, Chao Wang*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications, 12:297, https://doi.org/10.1038/s41467-020-20624-z. (2021) 
7.	Lei Yao , Chengyuan Liu, Ning Wang, Feng Du, Sijia Fan, Yujun Guo, Li Zhang, Yang Pan, Wei Xiong*. Cholesterol regulates cannabinoid analgesia through glycine receptors. Neuropharmacology, 177: 108242. doi: 10.1016/j.neuropharm.2020.108242. (2020)
8.	Lei Yao, Marta Wells, Xiongwu Wu, Yan Xu, Li Zhang*, Wei Xiong*. Membrane cholesterol dependence of cannabinoid modulation of glycine receptor. FASEB J, 34: 10920-10930 (2020)
9.	Guichang Zou#, Xin Zuo#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu, Wei Xiong*. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 30(12): 4209-4219 (2020)
10.	Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, Wei Xiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. Journal of Biological Chemistry. 295: 138-145 (2020)
11.	Xiaoqun Wang#, Yiwen Hou#, Zhuanghao Hou, Wei Xiong*, Guangming Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Analytical Chemistry, 91(4): 2719~2726 (2019)
12.	Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)
13.	Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 19: 634-646 (2019)
14.	Hongying Zhu#, Ning Wang#, Lei Yao, Qi Chen, Ran Zhang, Junchao Qian, Yiwen Hou, Weiwei Guo, Sijia Fan, Siling Liu, Qiaoyun Zhao, Feng Du, Xin Zuo, Yujun Guo, Yan Xu, Jiali Li, Tian Xue, Kai Zhong, Xiaoyuan Song, Guangming Huang*, Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell, 173, 1716-1727 (2018)
15.	Jieping Lu#*, Sijia Fan#, Guichang Zou, Yiwen Hou, Tao Pan, Weiwei Guo, Lei Yao, Feng Du, GE Homanics, Dan Liu, Li Zhang, Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224-232 (2018)
16.	Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang, Wei Xiong*,  Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114: 2586-2591 (2017)