1995-2000年，中国科学技术大学少年班系（强化班），学士
2000-2005年，美国约翰霍普金斯大学医学院，细胞分子生理学博士

 

光感受神经生物学的光信号转导、神经环路以及干细胞相关的感光细胞再生

2006-2011年，美国约翰霍普金斯大学医学院神经学系，博士后
2011-2012年，美国约翰霍普金斯大学医学院神经学系，助理研究员
2012年至今， 合肥微尺度交叉科学国家研究中心，教授
2012年至今， 中国科学技术大学生命科学与医学部，教授
2022年至今，	中国科学技术大学生命科学与医学部，讲席教授

1.2024	中国科学院杰出科技成就奖
2.2024	中国科学院五四青年奖章集体
3.2024	中国神经科学学会神经科学成就奖
4.2024	2023年度“中国科学十大进展”
5.2023	中国2023年度重要医学进展
6.2023	新基石研究员
7.2022	科学探索奖
8.2022	2022年度“中国神经科学重大进展”
9.2022	安徽省自然科学一等奖
10.2021	第十三届谈家桢生命科学创新奖
11.2021	张香桐神经科学青年科学家奖
12.2020	2020年度“中国神经科学重大进展”
13.2019	国家自然科学基金委杰出青年基金
14.2019	2019年度“中国生命科学十大进展”
15.2019	Cell杂志2019年最佳论文
16.2014	Human Frontier Science Program (HFSP), Young Investigator Grants
17.2013	国家自然科学基金委优秀青年基金	
18.2012	海外高层次人才引进计划青年项目
19.2007	Final list of Life Science Research Foundation Fellowships
20.2006	BEST BASIC SCIENCE PAPER by Circulation, AHA
21.2004	NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium
22.2003	American Heart Association (AHA) Scientific Sessions Selected                         
Late-Breaking Science

基金委优秀青年基金 （2013）、杰出青年基金（2019）、青年科学基金A类延续（2025）、基金委创新研究群体项目负责人（2021），科技部重点研发计划项目首席（2013、2020），中国科学院稳定支持基础研究领域青年团队负责人（2021），国际研究资助组织Human Frontier Science Program (HFSP) Young Investigator Grants（2014），新基石科学基金（2023）。

代表性论文：
(# equal contributions, *co-corresponding authors，†lead contact) 

1.Ma YQ#*, Chen YN#, Wang S#*, Chen ZH#, Zhang YW#, Huang L, Zhang XX, Yin F, Wang YX, Yang MZ, Li ZJ, Huang K, Fang X, Li ZS, Wang MH, Liu WH, Li JN, Li LF, Zhao H, Wei M, Shi YM, Liu R, Zhang M, Chen JT, Shen JW, Meng JJ, Yang YP, Zhang F*, Gong XL*, Han G*, and Xue T*† (2025). Near-Infrared Spatiotemporal Color Vision in Humans Enabled by Upconversion Contact Lenses. Cell. 188, 1-14. 
2.Shi YM#, Zhang JM#, Li XY, Han YC, Guan JH, Li YL, Shen JW, Tzvetanov T, Yang DY, Luo XY, Yao YC, Chu ZK, Wu TY, Chen ZP, Miao Y, Li YF, Wang Q, Hu JX, Meng JJ, Liao X, Zhou YF, Tao L, Ma YQ, Chen JT, Zhang M, Liu R*, Mi YY*, Bao J*, Li Z*, Chen XW*, Xue T*† (2025). Non-image-forming photoreceptors improve visual orientation selectivity and image perception. Neuron. 113, 1–15.
3.Miao Y#, Zhao H#*, Li YF#, SunYP, Bi R, Li HL, Fang X, Li ZS, Ma YH, Lv LB, An K, Meng JJ*, Yao YG*, and Xue T*† (2025). Light at night negatively affects mood in diurnal primate-like tree shrews via a visual pathway related to the perihabenular nucleus.”, PNAS, 2025. DOI.org/10.1073/pnas.2411280122
4.Meng JJ#, Shen JW#, Guang L, Ouyang CJ, Hu JX, Li ZS, Zhao H, Shi YM, Zhang M, Liu R, Chen JT, Ma YQ, Zhao H and Xue T *† (2023). Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis. Cell. 2023, 186 (2), 398-412.
5.Hu JX#, Shi YM#, Zhang JM, Huang XF, Wang Q, Zhao H, Shen JW, Chen ZP, Song W, Zheng P, Zhan SL, Sun YP, Cai PF, An K, Ouyang CJ, Zhao BZ, Zhou QX, Xu L, Xiong W,  Zhang Z, Meng JJ, Chen JT, Ma YQ, Zhao H, Zhang M, Qu K, Hu J, Luo MH, Xu FQ, Chen XW, Xiong Y, Bao J*, and Xue T*† (2022).  Melanopsin retinal ganglion cells mediate light-promoted brain development. Cell.  185, 3124-3137.e15
6.Yi WY#, Lu YF#, Zhong SJ#, Zhang M#*, Sun L, Dong H, Wang MD, Wei M, Xie HH, Qu HQ, Peng RM, Hong J, Yao ZQ,Tong YY,Wang W, Ma Q, Liu ZY, Ma YQ, Li SZ, Yin CH, Liu JW, Ma C, Wang XQ*,Wu Q*, and Xue T*† (2021). A single-cell transcriptome atlas of the aging human and macaque retina. National Science Review 8,  nwaa179, https://doi.org/10.1093/nsr/nwaa179
7.An K#, Zhao H#*, Miao Y, Xu Q, Li YF, Ma YQ, Shi YM, Shen JW. Meng JJ, Yao YG, Zhang Z, Chen JT, Bao J, Zhang M and Xue T*† (2020). A Circadian Rhythm-gated Subcortical Visual Circuit for Nighttime Light Induced Depressive-like Behaviors. Nature Neuroscience 23, 869-880.
8.Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*† (2020). Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC derived retinal organoids. Science Advances 6, eaay5247.
9.Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue  T*† (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell 177, 243-255 e215. Cell Best of 2019, Cell press (9 Best Articles which published in Cell in 2019)
10.Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*†  (2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advances 5, eaav3335.
11.Xue T*, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW* (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature 479, 67-73. (Faculty of 1000:  f1000.com/13360986).
代表性综述：

12.Meng JJ#, Huang XD#, Ren CR, Xue T (2025). Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells. Annual Review of Neuroscience 48, 211-229.
13.Shi YM, Hu JX, Xue T† (2025). Light, opsins, and life: Mammalian photophysiological functions beyond image perception. Neuron DOI: 10.1016/j.neuron.2025.05.025.
14.Rao F*, Xue T* (2024). Circadian-independent light regulation of mammalian metabolism. Nature Metabolism 6, 1000–1007. 
其他论文：

15.Cai Y#*, Gu YH#*, Zhang J#, Zhu Y, Ma Z, He Q, Sun YJ, Yuan MM, Li XJ, Zhu K, Miao BL, Zhao J, Liu J, Tang M, Tong DL, Feng LX, Ma M*, Zhong GS*, Qiu ZL*, and Xue T* (2025). An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients. Research 2025.  DOI.org/10.34133/research.0717
16.Shen JW, Xue T† (2025). Neural-circuit architecture underlying non-image-forming visual functions. Current Opinion in Neurobiology 2025, 93:103052. DOI.org/10.1016/j.conb.2025.103052
17.Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J*, Liu Q* (2024). Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism 36(5):1059-1075.e9. 
18.Xu H#, Wang S#, Fang M, Luo S, Chen C, Wan S, Wang R, Tang M, Xue T, Li B*, Lin J*, Qu K* (2023). SPACEL: deep learning-based characterization of spatial transcriptome architectures. Nature Communications 14(1):7603.
19.Wang HW, Wang S*, Zhou JY, Deng HX, Sun SS, Xue T, Ma YQ*, Gong XL* (2023). Bio-Inspired Semi-Active Safeguarding Design with Enhanced Impact Resistance via Shape Memory Effect. Advanced Functional Materials 33, 2212093.
20.Xiang N#, Li YJ#, Liu MY, Wu QQ, Zhang YX, Jin HZ, Wang Q, Li YW, Tong DL, Xue T, Jin TC*, Bao W, Chen Z* (2023). Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases. Rheumatology Advances in Practice 7(2):rkad064.
21.Ghanam AR, Ke SW, Wang SJ, Elgendy R, Xie CY, Wang SQ, Zhang R, Wei M, Liu WG, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song XY(2023). Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress. iScience 26(1):105740. 
22.Zhou P, Shen JW, Liang J, Xue T, Sun YS, Zhang LH*, Tian CL* (2023). Metabolic state oscillations in cerebral nuclei detected using two-photon fluorescence lifetime imaging microscopy,Chinese Chemical Letters Volume 34, Issue 1.
23.Tong DL#, Zhang M#, Yang YR#, Xia H#, Tong HY, Zhang HJ, Zeng WH, Liu MZY, Wu Y, Ma H, Hu X, Liu WY, Cai Y, Yao YF, Yao YC, Liu KP, Shan SF, Li YJ, Gao G, Guo WW, Peng Y, Chen SH, Rao JH, Zhao JX, Min J, Zhu QJ, Zheng YM, Liu LX, Shan C, Zhong K, Qiu ZL*, Jin TC*, Chiu S*, Yuan ZM*, Xue T*† (2023). Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques. Protein & Cell. 14(1):69-73
24.Khan MH#, Huang X#, Tian X, Ouyang C, Wang D, Feng S, Chen J, Xue T*, Bao J*, and Zhang X* (2022). Short- and long-term effects of 3.5-23.0 Tesla ultra-high magnetic fields on mice behaviour. European Radiology 10.1007/s00330-022-08677-8.
25.Li B, Zhang W, Guo C, Xu H, Li L, Fang M, Hu Y, Zhang X, Yao X, Tang M, Liu K, Zhao X, Lin J, Cheng L, Chen F, Xue T, Qu K*(2022). Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution. Nature Methods 19(6):662-670.
26.Tang HD, Dong WY, Hu R, Huang JY, Huang ZH, Xiong W, Xue T, Liu J*, Yu JM*,  Zhu X*, Zhang Z* (2022). A neural circuit for the suppression of feeding under persistent pain. Nature Metabolism https://doi.org/10.1038/s42255-022-00688-5
27.Ren J, Xue T, Wang L.(2022).  Shining more light on G protein signalling modules: a novel optogenetic tool for Gq activation. Science China Life Science, doi: 10.1007/s11427-022-2150-1. Online ahead of print 
28.Zou G, Xia J, Luo HY,  Xiao D, Jin J,  Miao CJ, Zuo X, Gao QQ, Zhang Z, Xue T, You YZ, Zhang Y, Zhang L, Xiong W* (2022). Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism 4, 1138–1149.
29.Li L, Zhao H*, Xie H, Akhtar T, Yao Y, Cai Y, Dong K, Gu Y, Bao J, Chen J, Zhang M, Zhong K, Xu W*, Xue T*† (2021). Electrophysiological characterization of photoreceptor-like cells in human inducible pluripotent stem cell-derived retinal organoids during in vitro maturation. Stem Cells 39，959-974.   
30.Li SZ#, Hu YZ#, Li YQ#, Hu M, Wang WC, Ma YQ, Cai Y, Wei M, Yao YC, Wang Y, Dong K, Gu YH, Zhao H, Bao J, Qiu ZL, Zhang M*, Hu XT*, Xue T*† (2021). Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina. Science Bulletin 66, 374-385.
31.Cheng P#, Tian X#, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, and He H. (2021). Direct control of store-operated calcium channels by ultrafast laser. Cell Research 7, 758-772.
32.Huang X#, Huang P#, Huang L#, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF*, Li H*, and Ren C*† (2021). A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment. Neuron 109, 347-362 e347.
33.Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C, and Liu Q*†. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron 109, 957-970 e8.
34.Zhang J, Gao F, Ma Y, Xue T, Shen Y*(2021). Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.  iScience. 24(11):103327.
35.Wang Y, Zeng W, Lin B, Yao Y, Li C, Hu W, Wu H, Huang J, Zhang M, Xue T, Ren D, Qu L, Cang C*(2021). CLN7 is an organellar chloride channel regulating lysosomal function. Science Advances 7(51):eabj9608. 
36.Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, Xie W, Zhang X, Cao P, Zhou W, Wang H, Farzinpour Z, Tao W, Song X, Zhang Y, Xue T, Jin Y, Li J, Zhang Z*.(2021) Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience 24(4):542-553.
37.Guo W, Fan S, Xiao D, Dong H, Xu G, Wan Z, Ma Y, Wang Z, Xue T, Zhou Y, Li Y, Xiong W*. (2021). A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications 12(1):6403. 
38.Liu Q#, Su LY#*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, and Yao YG*† (2020). Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biology 34, 101560.
39.Lu Y#, Shiau F#, Yi W#, Lu S, Wu Q, Pearson J, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien G, Sherman T, Duan X, Fertig D, Goff L, Zack J, Handa J, Xue T*, Bremner R*, Blackshaw S*,Wang X* and Clark B*† (2020). Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. Developmental Cell. 53, 473-491.
40.Akhtar T, Xie H, Khan MI, Zhang M*, Xue T*† (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium, Stem Cell Research, 39, 101491. 
41.Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Advanced Healthcare Materials, e1801132. (Review)
42.Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KF, Ren C*† (2019). A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron 102, 128-142 e128.
43.Zhu H#, Wang N#, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G*, Xiong W*† (2018). Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell 173, 1716-1727 e1717. 
44.Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M (2018). An unexpected INAD PDZ tandem-mediated PLCbeta binding in Drosophila photo receptors. Elife 7. doi:10.7554/eLife.41848
45.Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B*, Lin W* (2018). Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer biology & therapy 20, 52-64. 
46.Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B* (2018). Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports 10,1267-1281.
47.Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J*, Zheng G* (2018). Nanowire arrays restore vision in blind mice. Nature Communications 9, 786.
48.Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* (2018). Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. Journal of Biology Rhythms 33, 65-75.
49.Huang DF, Wang MY, Yin W, Ma YQ, Wang H, Xue T, Ren DL*, and Hu B*†. (2018). Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency. Frontiers in Behavioral Neuroscience 12, 53.
50.Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X(2017). A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. Journal of Clinical Investigation 127, 2631-2646.
51.Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Current Biology 27, 1791-1800.
52.Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP (2017). Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nature Communications 8, 14335.
53.Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chemical Communications (Camb)  51, 8153-6.
54.Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP (2014). Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. Journal of Biology Chemistry 289, 24215-2
55.Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications 5, 4047.
56.Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS 110, 4045-50.
57.Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR (2012). Restoration of vision after transplantation of photoreceptors. Nature 485, 99-103.
58.Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature 457, 281-7. (Faculty of 1000:  f1000.com/1144855).
59.Luo DG, Xue T, Yau KW (2008) How vision begins: An odyssey. PNAS 105, 9855-62  (Review)
60.Fu YB#, Kefalov V#, Luo DG#, Xue T#, Yau KW (2008). Quantal noise from human red cone pigment. Nature Neuroscience 11, 565-71
61.Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA (2007). Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation 115, 1839-1850.
62.El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Molecular Endocrinology 21, 753-764.
63.Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006).  A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model.  Circulation 114, 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.
64.Ardehali H, Xue T, Dong P, Machamer C (2005).  Targeting of the mitochondrial membrane proteins to the cell surface for functional studies.  Biochemical and Biophysical Research Communications 338, 1143-51.
65.Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005).  Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.  Circulation Research 97, 159-67.
66.Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reproductive Toxicology 20, 377-91.
67.Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005).  Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers.  Cardiovascular Research 67, 263-73.
68.Wang G#, Xue T#, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005).  Electrophysiological properties of pluripotent human and mouse embryonic stem cells.  Stem Cells 23, 1526-34. 
69.Xue T#, Cho H#, Akar F#, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005).  Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers.  Circulation 11, 111-20. Issue highlights, Best Paper Award, Circulation 2005
70.Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003).  Novel interactions identified between µ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry.  Biophysical Journal 85, 2299-310.
71.Azene EM#, Xue T#, Li RA (2003).  Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels.  Journal of Physiology 547, 349-356. 
72.Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003).  Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating.  Journal of Biology Chemistry 278, 13647-54.
73.Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003).  Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. Journal of Biology Chemistry 278, 8717-24.
74.Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. Journal of Biology Chemistry 277, 46233-42.
75.Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization.  Circulation Research 90, 1267-1273.
76.Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Letters 511, 159-164.

创新药物临床实验：
（1）国家药品监督管理局同意开展治疗湿性年龄相关性黄斑变性（wAMD）的药物临床试验（批准号CXSL2300839）
（2）国家药品监督管理局同意开展糖尿病黄斑水肿的药物临床试验（批准号CXSL2400355）
发明专利：
授权发明专利：
1.薛天、才源：用于在体基因治疗的基因编辑组合物或试剂盒，专利号：ZL201811144025.3 
2.薛天、金腾川、章梅、才源、童大力：腺相关病毒介导的新型冠状病毒抗体诱导物及疫苗组合物，专利号：ZL202010903143.9
3.薛天、马玉乾、陈雨诺、陈毅豪：红外视觉分辨的行为学检测方法及装置，专利号：ZL202211243888.2
申请中发明专利：
4.薛天、刘嵘、才源：可穿戴设备和健康监测方法，专利申请号：202211286207.0
5.薛天、马玉乾、陈雨诺、王胜、龚兴龙：软性角膜接触镜及其在红外视觉成像检测中的应用，专利申请号：202510036438.3
6.薛天、刘嵘、史逸铭、张家明、韩宇崇：一种显示方法、装置、设备和存储介质，专利申请号：2024118505292、
7.薛天、马玉乾、陈雨诺、王胜、龚兴龙：用于红外色彩视觉成像的软性角膜接触镜、制备方法以及检测方法，专利申请号：202510035772.7
8.薛天、马玉乾、陈雨诺、孟建军：用于红外图像视觉的上转换成像系统，专利申请号：202510035769.5